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In November 2024, the FDA green-lit a Phase 1 trial for the Arcturus Therapeutics self-amplifying (replicon) H5N1 "pandemic" bird flu injection (ARCT-2304):
These experimental replicon shots are primarily funded by BARDA with support from the Gates Foundation, who gave Arcturus Therapeutics a $928,563 grant in October 2024 to "improve understanding of durability of protection after administration of nucleic-acid based vaccines."