The Oxford-AstraZeneca Covid vaccine is being withdrawn worldwide, months after the pharmaceutical giant admitted for the first time in court documents that it can cause a rare and dangerous side effect.

The vaccine can no longer be used in the European Union after the company voluntarily withdrew its "marketing authorisation". The application to withdraw the vaccine was made on March 5 and came into effect on Tuesday.

Similar applications will be made in the coming months in the UK and in other countries that had approved the vaccine, known as Vaxzevria.

The decision to withdraw it brings to an end the use of the jab, which was heralded by Boris Johnson as a "triumph for British science" and credited with saving more than six million lives.

AstraZeneca said the vaccine was being removed from markets for commercial reasons. It said the vaccine was no longer being manufactured or supplied, having been superseded by updated vaccines that tackle new variants. 

Vaxzevria has come under intense scrutiny in recent months over a very rare side effect, which causes blood clots and low blood platelet counts. AstraZeneca admitted in court documents lodged with the High Court in February that the vaccine "can, in very rare cases, cause TTS".

TTS – which stands for Thrombosis with Thrombocytopenia Syndrome – has been linked to at least 81 deaths in the UK as well as hundreds of serious injuries. AstraZeneca is being sued by more than 50 alleged victims and grieving relatives in a High Court case.