Special Operations Forces (SOF) are some of the US' most elite military members, possessing outstanding physical and psychological resilience. Because of their expertise, SOF veterans are more likely to have more deployments, spend longer away from home, experience greater isolation, and be exposed to intense combat situations, all of which increase the likelihood of exposure to stress and trauma.

Traumatic brain injury (TBI) is commonly sustained during conflict, which makes comorbid psychological and neuropsychiatric issues, such as post-traumatic stress disorder (PTSD), depression, anxiety, and suicidal thoughts and behaviors, more likely.

Researchers at Ohio State University determined whether one clinical treatment with two different psychedelics improved mental health in the SOF veteran population.