Recent oncology studies reveal that plum-derived chlorogenic and neochlorogenic acids don't simply mop up free radicals. They act as bioactive signaling molecules, reprogramming cancer cell fate. Mechanisms documented in vitro and in vivo: • Mitochondrial apoptosis: Collapse of membrane potential (ΔΨm), cytochrome c release, and caspase-3/9 activation. • Death receptor activation: Fas/FasL signaling triggers extrinsic apoptosis. • ROS modulation: Tumor-selective oxidative stress overwhelms malignant cells, while normal cells remain protected. • Cell cycle arrest: Inhibition of CDK4/6 and cyclin D1 halts proliferation at G0/G1 and G2/M. • Gene regulation: Downregulation of Bcl-2, NF-κB, AKT/mTOR; upregulation of p53, Bax, and caspase cascades. • Anti-metastatic activity: VEGF suppression and reduced MMP-2/9 activity, limiting angiogenesis and invasion. The striking detail: IC50 values show selective cytotoxicity—plum polyphenols kill malignant cells at concentrations that leave healthy epithelial cells largely unharmed. This therapeutic precision is something chemotherapy rarely achieves. This is not "antioxidant housekeeping." This is molecular code embedded in fruit, restoring order where cancer breaks it.