At the University of Nottingham, researchers have created a ground-breaking biomimetic gel that can rebuild enamel, the hardest tissue in the human body and the only part of a tooth that cannot naturally regenerate.
Until now.

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The secret lies in mimicking how teeth originally form.

The gel uses engineered versions of amelogenin — a protein found in saliva that guides enamel growth during childhood. When applied to damaged teeth, it binds with calcium and phosphate ions to rebuild enamel crystal by crystal, in perfect alignment with your existing tooth structure.

Within just one week, the gel can regrow up to 10 micrometres of new enamel.
That means it can repair cracks, reverse early decay, smooth rough surfaces, and even reduce sensitivity — all without drills, fillings, or pain.

Fluoride can strengthen what you already have.
This technology actually creates new enamel, restoring the tooth to its natural state.

With over 3.7 billion people affected by cavities, this breakthrough could reshape dentistry entirely. Human trials are next — and if successful, the era of drilling and fillings could be replaced with a simple gel you apply like toothpaste.