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Environmental exposures have a lot to do with biological or cellular aging and, according to a December 2019 study, lead, mercury and perfluorooctanesulfonic acid (PFOS) are the three toxins shown to have the greatest impact on your life span

Biological aging is modifiable. Avoiding toxic exposures is one important aspect, but your diet, exercise and other lifestyle factors also play a role. One key for longevity is maintaining healthy insulin sensitivity, as insulin resistance is a hallmark of most chronic diseases

Lead and calcium are chemically very similar, making lead a competitor at the cellular level and disrupting many different bodily systems

Two of the most prevalent sources of mercury are dental amalgam and seafood. Europe paved the way for global change by banning the use of amalgam fillings in pregnant or nursing women and children under the age of 15 as of July 1, 2018

PFOS are associated with a wide array of health problems, including cancer, immune and thyroid dysfunction, low birth weight and more

Your biological age can provide a good clue about your longevity, far more so than your chronological age. Your biological age refers to the state of your cells — they can be younger or older than your calendar age, which means you're aging slower or faster than expected.

Environmental exposures have a lot to do with biological or cellular aging and, according to a December 2019 study1,2 published in The Journals of Gerontology, lead, mercury and perfluorooctanesulfonic acid (PFOS) are the three toxins shown to have the greatest impact on your life span.

While glyphosate was not included in this study, my guess is it would probably be a top contender as well, considering it disrupts normal body functions, especially your gut, and appears to enhance the damaging effects of other toxins.

According to Stephanie Seneff, Ph.D., a research scientist at the Massachusetts Institute of Technology, glyphosate worsens virtually all modern diseases which, of course, will shorten your life. That said, lead, mercury and PFOS have repeatedly been identified as significant contributors to chronic ill health and are certainly among the most pervasive and concerning toxins out there.

The Dangers of Lead Are Well-Recognized

As one might expect, the December 2019 study3 found that "biological age was elevated relative to actual age in people who had chronic disease," while those participating in a wellness program showed signs of slowed aging.

"This observation suggests that biological aging is modifiable," the researchers note, and that lowering your biological aging rate is "a sign of healthy aging." Strong predictors of biological age were measures of metabolic health, inflammation and toxic accumulation, with lead, mercury and PFOS being the most influential predictors.

In "The Heroes Who Sunk Lead," I review the history of lead and its impact on organ function, especially your brain. Importantly, there is no known safe exposure to lead, which often affects young children and lower socioeconomic groups the hardest.

Epidemiological studies have revealed African-American children have a higher incidence of lead poisoning, potentially from a slightly different way of metabolizing the heavy metal.

Lead and calcium are chemically very similar, making lead a competitor at the cellular level and disrupting many different bodily systems.4 In your neurological system, it may disrupt neurons that use calcium to transmit information.5

The presence of lead will cause some neurons to fire more and decrease the signals in others. This may alter neurological development in the brains of children who have absorbed lead from their environment.

The Public Health Heroes Who Fought to Lower Lead Exposure

One of the leaders in the fight against lead was Dr. Herbert Needleman, a pediatrician who saw firsthand the damage lead does to children. After years of treating children and observing the long-term effects of exposure, he maintained that a slow buildup of lead in the system could trigger symptoms even in the absence of overt poisoning.

As lead-based paint and gasoline were the biggest contributors to lead poisoning in children, Needleman and public health expert and colleague Dr. Philip Landrigan began lobbying to remove lead from these products. The industry fought back using paid experts to pick apart and publicly lambast the research. The industry also went after Needleman personally, trying to discredit him and destroy his career.

Another prominent player was geochemist Clair Patterson, Ph.D., who fought the oil companies to have lead removed from gasoline. Even when it was added to gas in the 1920s it was known to cause neurological damage. Still, the process was pursued as it enabled the oil companies to net greater profits.

In 1965, Patterson published the book, "Contaminated and Natural Lead Environments of Man,"6 in an attempt to bring the dangers of lead gasoline on health and environment to light.

Again, the industry brought to bear its influence to discredit the science and the man in an effort to maintain profits at the cost of human health. But despite the overwhelming odds, Patterson ultimately succeeded and was instrumental in bringing forth the 1975 U.S. mandated option of unleaded gas at the pumps.

In 1986, Patterson's persistence triggered the removal of lead from all gasoline in the U.S. altogether. As a result, Americans' blood lead levels dropped nearly 80% by the late 1990s. In my view, Patterson is one of the greatest unrecognized public health heroes of the 20th century.

Lead Exposure Continues To Be a Concern

The elimination of leaded gasoline didn't get rid of all lead exposures, however. As noted in a June 26, 2019, article7 in The Guardian, "hundreds of thousands of children in the U.S. remain at risk of exposure to lead, which causes cognitive and behavioral deficits."

Of the 31 states that have reported statistics on the percentage of children with elevated lead levels, Louisiana and Kentucky are among the worst.8 The U.S. Department of Housing and Urban Development estimates as many as 24 million U.S. residences built before 1978 still contain lead hazards, and in June 2019 announced $330 million in grants will be distributed to clean up lead and other safety hazards in low-income housing communities.9

A 2017 study10 also noted that many children with elevated lead levels remain undiagnosed. An estimated 1.2 million cases of elevated blood lead levels were thought to have occurred between 1999 and 2010, yet only 606,70911 were reported to the U.S. Centers for Disease Control and Prevention during that time, suggesting significant underreporting.

According to the authors, "Based on the best available estimates, undertesting of blood lead levels by pediatric care providers appears to be endemic in many states." Indeed, many pediatricians are likely to overlook factors such as lead exposure when faced with neurologically challenged children. This is a travesty, as your child's condition will surely continue to decline unless the lead accumulation is addressed and reduced through a comprehensive detoxification program.

Strategies to Avoid Lead Poisoning

The issue of preventing lead poisoning is a pressing matter, whether you have young children in your home or not. Harvard Medical School offers the following suggestions to protect yourself and your family against lead exposure:12

-Was your home built before 1978? If so, get it inspected to determine whether it has any lead paint

-Lead paint removal should be done by a certified professional to ensure safety. The dust is highly toxic. For more information on this, see the U.S. Environmental Protection Agency's "Lead-Based Paint Activities Professionals" page13

-Get your water tested for lead 

-Be mindful of the fact that certain household objects may contain lead. For information about lead-containing products and recalls, see the Consumer Products Safety Commission's website14

-Get your child tested for lead. Ideally, all children should be tested at ages 1 and 2, and again at ages 3 and 4 if you live in an older home. It's also recommended to test your child's level whenever there's concern about exposure. A level of 5 mcg/dL or higher is considered dangerous

The Dangers of Mercury

When it comes to mercury, two of the most prevalent sources are dental amalgam and seafood. Amalgam emits mercury vapor even after it is implanted into the body. This mercury is bioaccumulative and crosses the placenta to accumulate in fetuses, as well. Dental amalgam's mercury is a known health risk, especially for children, fetuses, nursing infants and people with impaired kidney function.

Mercury-based dental amalgam also pollutes water via dental clinic releases and human waste; air via cremation, dental clinic emissions, sludge incineration and respiration; and land via landfills, burials and fertilizer. Once in the environment, dental mercury converts to its even more toxic form: methylmercury and becomes a major source of mercury in the fish people eat.

For several years now, I've been working with Charlie Brown and the Consumers for Dental Choice to eliminate the use of amalgam in the U.S. and around the world. Europe paved the way for global change by banning the use of amalgam fillings in pregnant or nursing women and children under the age of 15 as of July 1, 2018.15

In the U.S., the Food and Drug Administration has been dragging its feet, but there are finally signs of movement. November 13, 2019, a scientific advisory panel gathered to review the science on mercury. Consumers for Dental Choice brought several talented speakers to testify.

The science committee, by consensus, called on FDA to end its silence on amalgam, and to start getting information about amalgam's risks to American patients, especially to vulnerable populations.

The question now is whether the agency will continue protecting the amalgam business at the expense of public health — which it has done for decades — and ignore the conclusions of its own scientific body. To learn more about this and for instructions on how you can submit a public comment to the FDA, see "Dentists Are Breaking Toxic Mercury Laws."

Avoid Amalgam at All Cost

Regardless of what the FDA decides, it's crucial to avoid amalgam if you want to protect your health and that of your children. Here are some general tips and guidelines: 

1. Find another insurance company or plan that pays for mercury-free fillings in all teeth, without exceptions or LEAT clauses.

2. If your current dentist is still using mercury in his or her practice — even if they also offer mercury-free options — seek out a dentist that offers only mercury-free fillings for all patients. And, be sure to inform your dentist about the reason you're transferring.

The reason for this is because dentists who still use amalgam end up using it on people who rarely have any other choice, either because they cannot afford to pay the difference, or their state or government program dictates they can only receive mercury.

This unfair practice needs to end, and the quicker we can get all dentists to go 100% mercury-free, the sooner these programs will be forced to change. So, selecting a 100% mercury-free dentist is an altruistic choice on your part, which will help those whose voices are so often ignored.

3. If you have mercury fillings, be sure to consult with a biological dentist who is trained in the safe removal of amalgam. For more information and guidance, see "How to Find a Biological Dentist That Can Treat You Holistically."

PFOS Contamination Is Pervasive

Per- and polyfluoroalykyl substances16,17 (PFAS) are widely used chemicals that make products water-, oil-, grease- and stain-resistant. The chemicals are also used in firefighting foam. One type, perfluorooctanoic acid (PFOA), is commonly found in older nonstick cookware.

PFOA and its cousin PFOS are associated with a wide array of health problems, including cancer, immune and thyroid dysfunction, low birth weight and more.18 Making matters all the worse, these chemicals take thousands of years to degrade and are found in groundwater across the country.19,20 As such, they're a considerable environmental threat.

Research21 by the U.S. Centers for Disease Control and Prevention published in 2007 found PFAS chemicals in the blood of more than 98% of Americans tested. PFOS was phased out starting in 2000.22,23 However, thanks to their persistence in the environment, they're still showing up in the strangest places — including food.

How do they get into your food? One is by way of sewage sludge, applied to farmland. Documents24 obtained by The Intercept reveal 44 samples of sewage sludge tested by the Maine Department of Environmental Protection all contained at least one PFAS chemical.

Another route is nonstick food wrappers. Research25,26 published in 2017 revealed 33% of fast food wrappers and containers contain fluorine, which suggests perfluorinated chemicals (PFCs) were used to give the paper that slick surface, and earlier studies27,28,29 have confirmed fluorinated chemicals can migrate from the packaging into the food.

More recently, food testing by the FDA (performed in 2017 as part of its Total Diet Study30 and presented at the 2019 meeting of the Society of Environmental Toxicology and Chemistry) reveals PFAS chemicals are in the U.S. food supply,31,32,33,34,35 and at levels far exceeding the advisory limit for PFOA and PFAS in drinking water (there's currently no limits in food).

Of the 91 foods tested for 16 types of PFAS, 10 were found to contain the chemicals.36 As reported by PBS:37

"PFOS, an older form of PFAS no longer made in the U.S., turned up at levels ranging from 134 parts per trillion to 865 parts per trillion in tilapia, chicken, turkey, beef, cod, salmon, shrimp, lamb, catfish and hot dogs."

How to Avoid Toxic PFCs

To minimize your family's exposure to toxic PFCs, avoid products that are stain-resistant, waterproof or nonstick, or that have been treated with flame retardant chemicals. The Environmental Working Group's "Guide to Avoiding PFCS"38 offers many helpful tips. Other suggestions that will help you avoid these dangerous chemicals include avoiding:

Items that have been pretreated with stain-repellants, and opt out of such treatments when buying new furniture and carpets.

Water- and/or stain-repellant clothing — One tipoff is when an item made with artificial fibers is described as "breathable." These are typically treated with polytetrafluoroethylene, a synthetic fluoropolymer.

Items treated with flame retardant chemicals39 — This includes a wide variety of baby items, padded furniture, mattresses and pillows. Instead, opt for naturally less flammable materials such as leather, wool and cotton.

Fast food and carry out foods — The wrappers are typically treated with PFCs.

Microwave popcorn — PFCs not only may present in the inner coating of the bag, but they also may migrate to the oil from the packaging during heating. Instead, use "old-fashioned" stovetop popcorn.

Nonstick cookware and other treated kitchen utensils — Healthier options include ceramic and enameled cast iron cookware, both of which are durable, easy to clean and completely inert, which means they won't release any harmful chemicals into your home.

Oral-B Glide floss and any other personal care products containing PTFE or "fluoro" or "perfluoro" ingredients — The EWG has an excellent database called Skin Deep40 you can peruse to find healthier options.

Unfiltered tap water — Unfortunately, your choices are limited when it comes to avoiding PFASs in drinking water. Either you must filter your water or obtain water from a clean source. Both solutions can be problematic and/or costly. While many opt for bottled water, it's important to realize that PFASs are not regulated in bottled water, so there's absolutely no guarantee that it'll be free of these or other chemicals. Bottled water also increases your risk of exposure to hazardous plastic chemicals such as bisphenol-A, which has its own set of health risks. Most common water filters available in supermarkets will not remove PFASs. You really need a high-quality carbon filtration system. The New Jersey Drinking Water Quality Institute recommends using granulated activated carbon "or an equally efficient technology" to remove PFC chemicals such as PFOA and PFOS from your drinking water.41 Activated carbon has been shown to remove about 90% of these chemicals.

Live Longer by Lowering Your Biological Age

If you're interested in living healthy for longer, minimizing toxic exposures is a crucial component, and the three toxins reviewed here — lead, mercury and PFOS — appear to have the greatest impact on biological aging. That said, other basic lifestyle factors such as diet cannot be overlooked.

As demonstrated in the featured study42 in The Journals of Gerontology, things like HbA1c also play an important role. High HbA1c is indicative of insulin resistance and Type 2 diabetes, both of which take a tremendous toll on your health and longevity.

Insulin resistance is at the heart of most chronic disease, and once it transitions into full-blown diabetes, you open yourself up to a variety of complications, including an increased risk for heart disease and Alzheimer's. So, in addition to avoiding toxic chemicals and heavy metals, you'll also want to avoid foods high in sugar and synthetic chemicals.

This means ditching processed foods and most restaurant food for home cooked whole food, ideally organic. You can also optimize your insulin sensitivity through resistance training (blood flow restriction training being particularly effective) and time-restricted eating.

Sources and References

1, 3, 42 The Journals of Gerontology: Series A; December 1, 2019; 74(Issue supplement): S52-S60

2 Rogue Health and Fitness December 2, 2019

4 Environmental Protection Agency, Learn About Lead

5 FitDay, Why Calcium is Essential for Healthy Brain Function

6 Archives of Environmental Health, Contaminated and Natural Lead Environments of Man

7, 8 The Guardian June 26, 2019

9 HUD.gov June 27, 2019

10 Pediatrics May 2017; 139(5): e20164266

11 AAP News April 27, 2017

12 Harvard Health Publications, February 2, 2016

13 Environmental Protection Agency, Lead-Based Paint Activities Professionals

14 U.S. Consumer Product Safety Commission, Total Lead Content

15 Noharm-europe.org December 9, 2016

16 EPA.gov PFAS

17 The Guardian May 23, 2019

18 EPA.gov Health effects from PFAS

19 EPA.gov, Health Advisory PFOA and PFOS

20 The Intercept, The Teflon Toxin Series

21 Environmental Health Perspectives 2007 Nov; 115(11): 1596–1602

22 EPA.gov 2010/2015 PFOA stewardship program

23, 33, 36 CNN Health June 3, 2019

24 Documentcloud.org, PFAS Summary of Sludge Data 053019 (PDF)

25 Environmental Science and Technology Letters February 1, 2017

26 Environmentalhealthnews.org February 1, 2017

27 Food Additives and Contaminants 2008: 25(3); 384-390

28 Food Additives and Contaminants 2005 Oct;22(10):1023-31

29 Journal of Agricultural and Food Chemistry 2007; 55(8): 3203-3210

30 FDA.gov Total diet study

31 The Guardian June 3, 2019

32 Chicago Tribune June 3, 2019

34 Business Insider June 4, 2019

35 Organic Prepper June 4, 2019

37 PBS June 3, 2019

38 EWG's Guide to Avoiding PFCS (PDF)

39 Green Science Policy, Flame Retardants

40 EWG Skin Deep Cosmetics Database

41 New Jersey Drinking Water Quality Institute, Recommendation on Perfluorinated Compound Treatment Options for Drinking Water, June 2015 (PDF)