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The failed Arizona gubernatorial and senatorial candidate is set to be appointed US Ambassador to Jamaica, according to nominations released by the White House Monday.
Lake will now have to be confirmed by the US Senate to the post, a feat she has yet to achieve in any of her previously selected roles.
Other notable nominations include Cameron Hamilton, who has been selected to lead the Federal Emergency Management Agency within the Department of Homeland Security for a second time.
Hamilton had been ousted by Kristi Noem after she moved to defund large parts of the agency, but he is up for another run at the job under the new leadership of Secretary Markwayne Mullin.
Make America Healthy Again crusader Casey Means also had her nomination for the role of Surgeon General withdrawn by the White House.
Presently, Lake serves as a senior advisor to the United States Agency for Global Media (USAGM). She was nominated to lead the Voice of America at the start of the Trump administration, but was never confirmed by the US Senate for the job.
The 56-year-old Lake is a former television anchor who became a vocal proponent of Trump's 2020 'big lie' - that widespread fraud cost him reelection.
That earned her two endorsements from the President, first when she ran and lost the 2022 Arizona governor's race for the Republicans to Democrat Katie Hobbs and, again, when she lost an Arizona Senate seat to Democrat Ruben Gallego two years later.
Despite a current role in the administration, it was reported last November that Lake had hoped to mount a third political run - this time for an Arizona House seat - which she later told the Daily Mail was not in the picture.
'That is not in my plans,' Lake said during a red carpet appearance at the then-newly renamed Trump Kennedy Center. 'I'm actually very happy working for the Trump administration,' she said, adding, 'I'm excited about work every day.'
She then made clear: 'So the answer is no.'
Earlier reporting by the Atlantic painted a pitiful picture of Lake waiting in the White House lobby to bend Trump's ear in October.
'Kari has been here for hours,' a White House aide revealed to the magazine. 'She's going to run and she's asking for an endorsement.'