Jimmy and guest Jeffrey Sachs highlight the newly announced Mecca joint agreement involving Turkey, Pakistan, and Saudi Arabia as evidence of a broader realignment in Middle Eastern security away from reliance on the United States. 

They contend that countries around the world increasingly view U.S. policy as unpredictable and are reconsidering who they should trade with, invest in, and rely on for security. They portray this as part of a larger shift in global politics that Trump's policies have accelerated, with countries seeking alternative alliances and partnerships to reduce their dependence on the United States.